DESIGN OF AN AFFINITY-BASED N-ALPHA-AMINO PROTECTING GROUP FOR PEPTIDE-SYNTHESIS - TETRABENZO[A,C,G,I]FLUORENYL-17-METHYL URETHANES (TBFMOC)

被引：30

作者：

RAMAGE, R

RAPHY, G

机构：

[1] Department of Chemistry, University of Edinburgh, Edinburgh, EH9 3JJ Scotland, West Mains Road

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 03期

关键词：

AFFINITY CHROMATOGRAPHY; POROUS GRAPHITIZED CARBON; TETRABENZO[A; C; G; I]FLUORENYL-17-METHANOL; TBFMOC N-ALPHA-PROTECTION;

D O I：

10.1016/S0040-4039(00)74138-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new N(alpha)-amino protecting group (Tbfmoc) has been designed to allow selective adsorption to porous graphitised carbon, thus allowing facile separation of N(alpha)-acetylated truncated peptides generated as impurities in solid phase peptide synthesis.

引用

页码：385 / 388

页数：4

共 17 条

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