IMMUNE-RESPONSE TO AN ALLERGENIC FRACTION OF SETARIA-DIGITATA IN HUMAN FILARIASIS

被引：15

作者：

BEURIA, MK ^{[1
]}

DAS, MK ^{[1
]}

机构：

[1] ICMR, REG MED RES CTR, NANDANKANAN RD, BHUBANESWAR 751016, INDIA

来源：

JOURNAL OF BIOSCIENCES | 1992年 / 17卷 / 04期

关键词：

FILARIAL ALLERGEN; ANTIBODY ISOTYPES; SETARIA-DIGITATA; ITH RESPONSE; HUMAN FILARIASIS;

D O I：

10.1007/BF02720100

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A low molecular weight antigenic fraction has been isolated from saline-soluble extracts of cattle filarial parasite Setaria digitata. This glycoprotein fraction (Fr III) which appears to have low phosphorylcholine content cross-reacted with infective larval (L3) antigens of Wuchereria bancrofti. Binding of human chronic filarial serum with L3 antigens could be inhibited partially by Fr III. The fraction elicited immediate cutaneous hypersensitivity reaction in people living in Wuchereria bancrofti endemic regions. The proportion of skin test positive cases was found to be highest in endemic normals in contrast to infected cases. IgE levels were however not different in chronic filariasis and in endemic normals (or in asymptomatic microfilaraemic carriers). On the other hand, specific IgG level was considerably enhanced only in chronic filariasis.

引用

页码：453 / 461

页数：9

共 19 条

[1]

BLOCH EF, 1985, ANN ALLERGY, V54, P83

[2] THE HYPERSENSITIVITY RESPONSE TO THE ADULT WORM PROTEINASE, SMW32, IN SCHISTOSOMA-MANSONI INFECTED MICE [J].

CHAPPELL, CL ;

KALTER, DC ;

DRESDEN, MH .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1988, 39 (05) :463-468

[3] INDUCTION OF A PROTECTIVE IMMUNE IGE RESPONSE IN RATS BY INJECTION OF DEFINED ANTIGENS OF SCHISTOSOMULUM-RELEASED PRODUCTS - IMMUNOCHEMICAL PROPERTIES OF THE TARGET ANTIGENS [J].

DAMONNEVILLE, M ;

AURIAULT, C ;

THOREL, T ;

VERWAERDE, C ;

PIERCE, A ;

STRECKER, G ;

CAPRON, A .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1986, 79 (03) :320-328

[4] THE INCIDENCE OF FILARIA AS AN ETIOLOGIC FACTOR FOR TESTICULAR HYDROCELE [J].

DANDAPAT, MC ;

MOHAPATRO, SK ;

MOHANTY, SS .

BRITISH JOURNAL OF SURGERY, 1986, 73 (01) :77-78

[5]

DAS MK, 1988, ACTA TROP, V45, P387

[6]

DAS MK, 1992, IN PRESS INT ARCH AL

[7] LIPOSOMES AS CARRIERS FOR PRODUCTION OF SUGAR SPECIFIC ANTIBODIES - PREPARATION OF ANTIGALACTOSYL ANTISERUM [J].

DAS, PK ;

GHOSH, P ;

BACHHAWAT, BK ;

DAS, MK .

IMMUNOLOGICAL COMMUNICATIONS, 1982, 11 (01) :17-24

[8]

HUSSAIN R, 1986, J IMMUNOL, V136, P1859

[9] A REVIEW OF IMMUNOLOGIC METHODS FOR DIAGNOSIS OF FILARIASIS [J].

KAGAN, IG .

JOURNAL OF PARASITOLOGY, 1963, 49 (05) :773-+

[10]

KALRA NL, 1976, J COMMUNICABLE DIS, V8, P337

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