ANTARELIX (EP-24332) A NOVEL WATER-SOLUBLE LHRH ANTAGONIST

被引：45

作者：

DEGHENGHI, R

BOUTIGNON, F

WUTHRICH, P

LENAERTS, V

机构：

[1] Europeptides, 95/08 Argenteuil, 9 avenue du Marais, Bt Aristote

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1993年 / 47卷 / 2-3期

关键词：

LHRH ANTAGONIST; HISTAMINE RELEASE; WATER SOLUBILITY;

D O I：

10.1016/0753-3322(93)90299-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel water soluble LHRH antagonist (EP 24332 - Antarelix) is described. Its activity in vitro and in vivo in several animal models is given. Antarelix (Ac-D-Nal, D-Cpa, D-Pal, Ser, Tyr, D-Hci, Leu, Lys-(iPr), Pro, D-Ala-NH2) in view of its potency, modest histamine - liberating activity and high water solubility has been selected for further development.

引用

页码：107 / 110

页数：4

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