A NEW AND CONVENIENT METHOD FOR THE SYNTHESIS OF 3-ALKYL THIOPHENES

被引：7

作者：

FAHMI, K ^{[1
]}

FACHE, F ^{[1
]}

LEMAIRE, M ^{[1
]}

机构：

[1] UNIV LYON 1,ESCIL,CATALYSE & SYNTH ORGAN,CNRS,UP 5401,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

来源：

JOURNAL OF MOLECULAR CATALYSIS | 1993年 / 80卷 / 02期

关键词：

ALKYL THIOPHENES; BENZYLIC ALCOHOLS; GRIGNARD REACTION; PALLADIUM REDUCTION;

D O I：

10.1016/0304-5102(93)85078-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A two step synthesis of 3-alkylthiophenes with an overall yield of 80% is described. The first step, a Grignard reaction, has been considerably improved by decreasing the amount of by-products. The second and key step of the synthesis, the reduction of a benzylic alcohol, has been studied in detail. The best results were obtained with PdCl2 in acetic acid, at 65-degrees-C under atmospheric pressure of H-2.

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收藏

页码：201 / 208

页数：8

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