CATALYTIC ASYMMETRIC-SYNTHESIS OF A FUNCTIONALIZED INDOLIZIDINE DERIVATIVE - A USEFUL INTERMEDIATE SUITABLE FOR THE SYNTHESIS OF VARIOUS GLYCOSIDASE INHIBITORS

被引：77

作者：

NUKUI, S ^{[1
]}

SODEOKA, M ^{[1
]}

SHIBASAKI, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(00)74058-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indolizidine derivative 7 has been synthesized in up to 86% ee by an asymmetric Heck reaction (Pd(0)-BPPFOH, Ag-exchanged zeolite) starting with prochiral alkenyl iodide 5. Conversion of 7 to delta-coniceine (9) is also described.

引用

页码：4965 / 4968

页数：4

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