GP120-INDUCED PROGRAMMED CELL-DEATH IN RECENTLY ACTIVATED T-CELLS WITHOUT SUBSEQUENT LIGATION OF THE T-CELL RECEPTOR

被引：25

作者：

FOSTER, S

BEVERLEY, P

ASPINALL, R

机构：

[1] CHELSEA & WESTMINSTER HOSP, CHARING CROSS & WESTMINSTER MED SCH, DEPT IMMUNOL, LONDON SW10 9NH, ENGLAND

[2] ST MARYS HOSP, SCH MED, DEPT MED, RESP UNIT, LONDON, ENGLAND

[3] UCL, SCH MED, IMPERIAL CANC RES FUND, TUMOUR IMMUNOL UNIT, LONDON W1N 8AA, ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 06期

关键词：

GP120; ACTIVATED T CELLS; PROGRAMMED CELL DEATH;

D O I：

10.1002/eji.1830250644

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In most individuals, HIV infection is characterized by a progressive decline in the number of peripheral blood CD4(+) T lymphocytes, and while the number of CD4(+) cells is within the normal range, defects in immune function are detectable. To date neither the decline in function nor the decline in cell number have been satisfactorily explained. Here we describe a mechanism which may contribute to the immunodeficiency and decline in CD4(+) cell numbers in HIV-infected individuals. We show that recently activated T cells are susceptible to apoptosis when exposed to HIV gp120 in the presence of anti-gp220 antibody.

引用

页码：1778 / 1782

页数：5

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