INCLUSION COMPOUNDS IN PHARMACEUTICAL ANALYSIS .I. DETERMINATION OF DIENESTROL IN DIENESTROL CREAM

被引：6

作者：

FORMAN, BJ

GRADY, LT

机构：

[1] Drug Standards Laboratory of the American Pharmaceutical Association Foundation, Washington, District of Columbia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 10期

关键词：

Column chromatography–separation; Dienestrol creams–analysis; Monostearin removal; dienestrol creams–urea inclusion compound; Polarography; organic–analysis;

D O I：

10.1002/jps.2600581024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Large ratios of monostearin to dienestrol in cream formulations complicate the development of an assay for dienestrol. Monostearin was removed easily in a test‐tube procedure by channel‐type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarography of the nitrosophenol derivative. Urea inclusion may offer a general approach to analytical methodology where long‐chain compounds need be separated from active ingredients. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1262 / &

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