MEMBRANE INSTABILITY INDUCED BY PURIFIED MYELIN COMPONENTS - ITS POSSIBLE RELEVANCE TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

被引：38

作者：

MONFERRAN, CG ^{[1
]}

MAGGIO, B ^{[1
]}

ROTH, GA ^{[1
]}

CUMAR, FA ^{[1
]}

CAPUTTO, R ^{[1
]}

机构：

[1] UNIV NACL CORDOBA, FAC CIENCIAS QUIM, DEPT QUIM BIOL, CORDOBA 5000, ARGENTINA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 553卷 / 03期

关键词：

(Lipid monolayers); Encephalomyelitis; Membrane fusion; Myelin basic protein; Proteolipid; Sulfatide;

D O I：

10.1016/0005-2736(79)90297-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fusogenic properties of purified myelin components in a system employing chicken erythrocytes were studied. Sulfatides, myelin basic protein and the apoprotein of Folch-Lees proteolipid were capable of individually inducing membrane fusion in the presence of Ca2+. Cerebrosides or a mixture of sulfatides and myelin basic protein (molar ratio 19:1) did not show such effect. The fusogenic ability of sulfatide was correlated to its behavior in mixed monolayers with phospholipids at the air-water interface. Mixed films of sulfatides with phosphatidylcholine or sphingomyelin but not with phosphatidylethanolamine showed reductions of molecular packing and surface potential similar to those found for other fusogenic compounds. The effects of myelin components described could be of importance in the membrane instability and vesicular disruption of myelin occurring in demyelinative disorders.

引用

页码：417 / 423

页数：7

共 38 条

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