ENALAPRIL-ASSOCIATED ACUTE-RENAL-FAILURE IN RENAL-TRANSPLANTS - POSSIBLE ROLE OF CYCLOSPORINE

被引：45

作者：

MURRAY, BM ^{[1
]}

VENUTO, RC ^{[1
]}

KOHLI, R ^{[1
]}

CUNNINGHAM, EE ^{[1
]}

机构：

[1] SUNY BUFFALO,DEPT MED,DIV NEPHROL,BUFFALO,NY 14260

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1990年 / 16卷 / 01期

关键词：

angiotensin-converting enzyme inhibitor; Cyclosporine; renal failure; transplantation;

D O I：

10.1016/S0272-6386(12)80787-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute deterioration of renal function occurred shortly after the angiotensin-converting enzyme (ACE) inhibitor, enalapril, was administered to two renal transplant patients who were also receiving cyclosporine. Renal function recovered completely in both cases upon discontinuation of enalapril. Neither patient had evidence of transplant artery stenosis or chronic rejection, conditions known to predispose to renal failure during ACE inhibitor therapy. The possibility that afferent vasoconstriction induced by cyclosporine may have predisposed these patients to renal failure from enalapril is discussed. © 1990, National Kidney Foundation, Inc.. All rights reserved.

引用

页码：66 / 69

页数：4

共 15 条

[1] CYCLOSPORINE IN THERAPEUTIC DOSES INCREASES RENAL-ALLOGRAFT VASCULAR-RESISTANCE [J].