FACTORS-V AND FACTORS-VII ANTICOAGULANT ACTIVITIES IN THE SALIVARY-GLANDS OF FEEDING DERMACENTOR-ANDERSONI TICKS

被引:50
作者
GORDON, JR [1 ]
ALLEN, JR [1 ]
机构
[1] UNIV SASKATCHEWAN, WESTERN COLL VET MED, DEPT VET MICROBIOL, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA
关键词
D O I
10.2307/3282577
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The salivary glands of Dermacentor andersoni ticks possess anticoagulant activities that can alter the clotting time of rabbit whole blood. Salivary gland extracts from female ticks inhibit both the intrinsic and extrinsic coagulation systems, and maximal activities against both pathways occur when the ticks attain about 250 mg feeding weight. These anticoagulants are directed against both coagulation factors V and VII, but they do not affect factors II or X. Despite this salivary anticoagulant activity, heavily tick-infested rabbits suffer no visible alteration of their peripheral blood coagulability and have no detectable circulating fibrin degradation products, suggesting that the ticks do not secrete a factor with fibrinolytic activity.
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页码:167 / 170
页数:4
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