CRYSTAL-STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MISPAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)

被引：73

作者：

WEBSTER, GD

SANDERSON, MR

SKELLY, JV

NEIDLE, S

SWANN, PF

LI, BF

TICKLE, IJ

机构：

[1] INST CANC RES,CANC RES CAMPAIGN,BIOMOLEC STRUCT UNIT,SUTTON SM2 5NG,SURREY,ENGLAND

[2] UNIV LONDON UNIV COLL,DEPT BIOCHEM,LONDON WC1E 6BT,ENGLAND

[3] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,LONDON WC1E 7HX,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 17期

关键词：

DNA structure; X-ray crystallography;

D O I：

10.1073/pnas.87.17.6693

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 Å and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti)·A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (>6 Å) minor groove.

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页码：6693 / 6697

页数：5

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