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DEREGULATION OF A HOMEOBOX GENE, HOX11, BY THE T(10-14) IN T-CELL LEUKEMIA

被引：382
作者：
HATANO, M
ROBERTS, CWM
MINDEN, M
CRIST, WM
KORSMEYER, SJ
机构：
[1] WASHINGTON UNIV, SCH MED, HOWARD HUGHES MED INST, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, DEPT MED, ST LOUIS, MO 63110 USA
[3] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA
[4] PRINCESS MARGARET HOSP, TORONTO M4X 1K9, ONTARIO, CANADA
[5] ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA
[6] UNIV TENNESSEE, CTR HLTH SCI, COLL MED, DEPT PEDIAT, MEMPHIS, TN 38163 USA
[7] PEDIAT ONCOL GRP, ST LOUIS, MO USA
来源：
SCIENCE | 1991年 / 253卷 / 5015期
关键词：
D O I：
10.1126/science.1676542
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment l0q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.
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页码：79 / 82
页数：4
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