TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE

被引:33
作者
NIWA, H
MIYACHI, Y
OKAMOTO, O
UOSAKI, Y
KURODA, A
ISHIWATA, H
YAMADA, K
机构
关键词
D O I
10.1016/S0040-4020(01)89003-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A total synthesis of the natural enantiomer of integerrimine (1), a twelve-membered dilactonic pyrrolizidine alkaloid of retronccine type has been achieved through the enantioselective synthesis and regioselective coupling of (+)-retronecine (4) and (+)-integerrinecic acid (methylthio)methyl ether (6).
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页码:393 / 412
页数:20
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