EVALUATION OF SPRAY-DRYING AS A METHOD FOR POLYLACTIDE AND POLYLACTIDE-CO-GLYCOLIDE MICROSPHERE PREPARATION

被引：62

作者：

PAVANETTO, F

GENTA, I

GIUNCHEDI, P

CONTI, B

机构：

[1] Dipartimento di Chimica Farmaceutica, Università di Pavia, 27100, Pavia

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 04期

关键词：

D O I：

10.3109/02652049309015325

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polylactide and polylactide-co-glycolide microspheres containing a lipophilic model drug (vitamin D3) were prepared by spray drying. The purpose of this work is to evaluate the efficacy of spray drying as a method for microsphere preparation. The study was carried out on five different polymers of lactide class: poly-L-lactide 57000 MW, poly-D,L-lactide 209000 MW, 109000 MW, 16000 MW, and polylactide-co-glycolide 22000 MW. The process conditions were experimentally assessed for each polymer used. The microspheres obtained were characterized for their shape, size and drug content, and the influence of the polymer on microsphere characteristics was evaluated. Results show that polymer type, polymer molecular weight and its concentration in the spraying solution greatly affect microsphere characteristics. In vitro dissolution tests performed with the rotating bottle method resulted in different release profiles depending on type of polymer and on microsphere morphology.

引用

页码：487 / 497

页数：11

共 12 条

[1]

Abe E., Miyaura C., Sakagami H., Takeda M., Konno K., Yamazaki T., Yoshiki S., Suda T., Differentiation of mouse myeloid leukemia cells induced by 1,25-dihydroxy vitamin D3, Proceedings of the National Academy of Sciences, USA, 78, pp. 4990-4993, (1981)

[2]

Arshady R., Albumin microspheres and microcapsules: methodology of manufacturing techniques, Journal of Controlled Release, 14, pp. 111-131, (1990)

[3]

Alessiani M., Maestri M., Rescigno G., Dionigi P., Albizzati E., Zonta A., Histological and chemical local reactions to implantable lactic and glycolic acids copolymers, Enzymes in Surgical Research, 21, pp. 47-48, (1989)

[4]

Conti B., Pavanetto F., Genta I., The use of polylactic acid for the preparation of microparticulate drug delivery systems, Journal of Microencapsulation, 9, 2, pp. 153-166, (1992)

[5]

Conti B., Pavanetto F., Genta I., Gandini C., Microsfere biodegradabili per la somministrazione parenterale della vitamina D3, Acta Technologiae et Legis Medicamenti, 1, pp. 101-112, (1990)

[6]

Eisman J.A., Frampton R.J., Effects of 1,25 dihydroxy-vitamin D3 metabolites and analogues on human breast cancer and malignant melanoma cells, Endocrine Control of Bone and Calcium Metabolism, pp. 237-238, (1984)

[7]

Jalil R.U., Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) polymers in sustained drug delivery, Drug Development and Industrial Pharmacology, 16, 16, pp. 2353-2367, (1990)

[8]

Jalil R., Nixon J.R., Microencapsulation using poly(L-lactic acid) I: microcapsule properties affected by the preparative technique, Journal of Microencapsulation, 6, pp. 473-484, (1989)

[9]

Pavanetto F., Conti B., Genta I., Giunchedi P., Solvent evaporation, solvent extraction and spray drying for polylactide microspheres preparation, International Journal of Pharmaceutics, 84, pp. 151-159, (1992)

[10]

Sato T., Kanke M., Schroeder H.G., De Luca P.P., Porous biodegradable microspheres for controlled drug delivery. I: Assessment of process conditions and solvent removal techniques, Pharmacological Research, 5, pp. 21-30, (1988)

← 1 2 →