MAGNETIC TARGETING OF A THERAPEUTIC ANTIBODY USING MAGNETOTROPIC MICROSPHERES OF THE INTERPOLYELECTROLYTE COACERVATION COMPLEX

被引：4

作者：

KIRPOTIN, DB

KINNE, R

MILTON, A

PALOMBOKINNE, E

EMMRICH, F

机构：

[1] MAX PLANCK SOC,RES UNIT RHEUMATOL IMMUNOL,W-8520 ERLANGEN,GERMANY

[2] AN BACH BIOCHEM INST,MOSCOW 117071,RUSSIA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1993年 / 122卷 / 1-3期

关键词：

D O I：

10.1016/0304-8853(93)91108-J

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The therapeutic monoclonal antibody OX35 was successfully localized in the ankle joint of arthritic rats in vivo using a permanent magnet and magnetotropic microspheres composed of a protamine-chondroitin sulphate complex. The microspheres formed at nearly stoichiometric quantities of the polyelectrolytes and quantitatively incorporated both magnetite and antibody. The release of immunologically active antibody from the microspheres was controlled by glutaraldehyde treatment.

引用

页码：354 / 359

页数：6

共 11 条

[1]

BILLINGHAM MEJ, 1989, THERAPEUTIC APPROACHES TO INFLAMMATORY DISEASES, P242

[2]

FRAKER PJ, 1978, BIOCHEM BIOPH RES CO, V80, P849, DOI 10.1016/0006-291X(78)91322-0

[3] AUTHENTIC T-HELPER CD4-(W3/25) ANTIGEN ON RAT PERITONEAL-MACROPHAGES [J].