NONINVASIVE INVIVO PERCUTANEOUS-ABSORPTION MEASUREMENTS USING X-RAY-FLUORESCENCE

被引：5

作者：

ROBERTSON, JD

FERGUSON, E

JAY, M

STALKER, DJ

机构：

[1] UNIV KENTUCKY,COLL PHARM,LEXINGTON,KY 40506

[2] UPJOHN CO,KALAMAZOO,MI 49007

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 11期

关键词：

PERCUTANEOUS ABSORPTION; TOPICAL DELIVERY; X-RAY FLUORESCENCE SPECTROMETRY; 5-IODOURACIL;

D O I：

10.1023/A:1015850627370

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

X-ray fluorescence (XRF) has been used to determine in vivo the percutaneous absorption of 5-iodouracil (5IU) in dimethyl sulfoxide (DMSO) on female Sprague-Dawley rats. An average absorption rate constant of 122 +/- 34 mug/cm2-hr was obtained from the XRF measurements on four rats. A comparative study was performed with radiolabeled (I-125) 5IU in which the absorption rate constant was determined to be 126 +/- 20 mug/cm2-hr. The XRF system described provides a simple, noninvasive means of measuring the percutaneous absorption rate of select compounds by the surface disappearance method.

引用

页码：1410 / 1414

页数：5

共 11 条

[1] SKIN PERMEABILITY IN-VIVO - COMPARISON IN RAT, RABBIT, PIG AND MAN [J].