EXPRESSION OF ELECTROSTATIC BINDING COOPERATIVITY IN THE RECOGNITION OF CELL-WALL PEPTIDE ANALOGS BY VANCOMYCIN GROUP ANTIBIOTICS

被引：38

作者：

GROVES, P ^{[1
]}

SEARLE, MS ^{[1
]}

WESTWELL, MS ^{[1
]}

WILLIAMS, DH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CAMBRIDGE CTR MOLEC RECOGNIT,CHEM LABS,CAMBRIDGE CB2 1EW,CAMBS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 13期

关键词：

D O I：

10.1039/c39940001519

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The strength of the binding interaction of the carboxylate group of peptide cell-wall analogues with ristocetin A is shown, by H-1 NMR studies of hydrogen bonded NHs, to increase towards a limiting value as the number of interactions on the same ligand template increases; the carboxylate electrostatic binding energy appears to reflect the whole set of linked weak interactions as a cooperative unit, and this cooperative effect is distinct from the classical chelate effect.

引用

页码：1519 / 1520

页数：2

共 9 条

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