TARGETED GENE REPLACEMENT - RESEARCHERS CAN NOW CREATE MICE BEARING ANY CHOSEN MUTATIONS IN ANY KNOWN GENE - THE TECHNOLOGY IS REVOLUTIONIZING THE STUDY OF MAMMALIAN BIOLOGY

被引：146

作者：

CAPECCHI, MR

机构：

来源：

SCIENTIFIC AMERICAN | 1994年 / 270卷 / 03期

关键词：

D O I：

10.1038/scientificamerican0394-52

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

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页码：52 / 59

页数：8

相关论文

共 3 条

[1] THE NEW MOUSE GENETICS - ALTERING THE GENOME BY GENE TARGETING
CAPECCHI, MR
[J]. TRENDS IN GENETICS, 1989, 5 (03) : 70 - 76
[2] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION
CAPECCHI, MR
[J]. SCIENCE, 1989, 244 (4910) : 1288 - 1292
[3] REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5
CHISAKA, O
CAPECCHI, MR
[J]. NATURE, 1991, 350 (6318) : 473 - 479