A CONTROLLED-STUDY OF RANITIDINE FOR THE PREVENTION OF RECURRENT HEMORRHAGE FROM DUODENAL-ULCER

被引:100
作者
JENSEN, DM
CHENG, S
KOVACS, TOG
RANDALL, G
JENSEN, ME
REEDY, T
FRANKL, H
MACHICADO, G
SMITH, J
SILPA, M
VANDEVENTER, G
机构
[1] UNIV CALIF LOS ANGELES, CTR ULCER RES & EDUC, LOS ANGELES, CA 90024 USA
[2] W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA USA
[3] VALLEY MED CTR, VAN NUYS, CA USA
[4] ALTON OCHSNER MED FDN & OCHSNER CLIN, NEW ORLEANS, LA 70121 USA
[5] HIGHLAND HOSP, OAKLAND, CA USA
关键词
D O I
10.1056/NEJM199402103300602
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Hemorrhage is the most common complication of duodenal ulcer disease, but there is little information about the effectiveness and safety of long-term maintenance therapy with histamine H-2-receptor blockers. Methods. We conducted a double-blind study in patients with endoscopically documented hemorrhage from duodenal ulcers. Patients were randomly assigned to maintenance therapy with ranitidine (150 mg at night) or placebo and were followed for up to three years. Endoscopy was performed at base line (to document that the ulcers had healed), at exit from the study, and when a patient had persistent ulcer symptoms unrelieved by antacids or had gastrointestinal bleeding. Symptomatic relapses without bleeding were treated with ranitidine; if the ulcer healed within eight weeks, the patient resumed taking the assigned study medication. Results. The two groups were similar at entry, which usually occurred about three months after the index hemorrhage. After a mean follow-up of 61 weeks, 3 of the 32 patients treated with ranitidine had recurrent hemorrhage, as compared with 12 of the 33 given placebo (P<0.05). Half the episodes of recurrent bleeding were asymptomatic. One patient in the ranitidine group withdrew from the study because of asymptomatic thrombocytopenia during the first month. Conclusions. For patients whose duodenal ulcers heal after severe hemorrhage, long-term maintenance therapy with ranitidine is safe and reduces the risk of recurrent bleeding.
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页码:382 / 386
页数:5
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