A ONE-STEP SYNTHESIS OF PSEUDOEPHEDRINE GLYCINAMIDE, A VERSATILE PRECURSOR FOR THE SYNTHESIS OF ALPHA-AMINO-ACIDS

被引：35

作者：

MYERS, AG

YOON, TY

GLEASON, JL

机构：

[1] Contribution No. 9087 Arnold and Mabel Beckman Laboratories, Chemical Synthesis California Institute of Technology, Pasadena

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)00820-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of pseudoephedrine glycinamide [(+)- or (-)-1] were synthesized by either of two procedures: (1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.

引用

页码：4555 / 4558

页数：4