DEGRADATION MECHANISMS FOR WATER-SOLUBLE DRUGS IN SOLID DOSAGE FORMS

被引：54

作者：

CARSTENSEN, JT

OSADCA, M

RUBIN, SH

机构：

[1] Hoffmann-La Roche, Inc., Nutley, New Jersey

[2] Extension Services in Pharmacy and the School of Pharmacy, University of Wisconsin, Madison, Wisconsin

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 05期

关键词：

Degradation; drug—solid dosage forms; Mechanism—thiamine degradation; solid dosage forms; Model—thiamine degradation; tablets; Solid dosage forms—water‐soluble drug degradation; Thiamine degradation; tablets—moisture effect;

D O I：

10.1002/jps.2600580504

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiamine hydrochloride, when tableled with magnesium stearate and microcrystalline cellulose, degrades in a pattern whereby an apparent equilibrium is reached. The amount of intact thiamine at equilibrium depends on the amount of moisture present and exhibits a minimum at about 5,5 percent moisture content. A model is proposed to explain this phenomenon. Thiamine dissolved in the water present adsorbs on the microcrystalline cellulose and the thiamine present in the monolayer degrades totally, whereas the thiamine in layers beyond the monolayer does not degrade. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：549 / +

页数：1

共 12 条

[1] MOISTURE STRESS TESTS IN STABILITY PROGRAMS [J].