CAN THE STRUCTURE OF PROTEINS BE CALCULATED

被引：6

作者：

JAHNIG, F ^{[1
]}

EDHOLM, O ^{[1
]}

机构：

[1] ROYAL INST TECHNOL, DEPT THEORET PHYS, S-10044 STOCKHOLM 70, SWEDEN

来源：

ZEITSCHRIFT FUR PHYSIK B-CONDENSED MATTER | 1990年 / 78卷 / 01期

关键词：

D O I：

10.1007/BF01317366

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

In contrast to soluble proteins, membrane proteins offer the possibility, to predict their secondary structure with some reliability. Based on such predictions a set of initial conformation can be constructed on which molecular dynamics simulations are performed in order to find the most stable state. The important point is that all those degrees of freedom which change slowly in time must be varied artificially in the set of initial conformations. This procedure is demonstrated for the membrane protein bacteriorhodopsin. © 1990 Springer-Verlag.

引用

页码：137 / 143

页数：7

共 23 条

[1] MOLECULAR-DYNAMICS WITH COUPLING TO AN EXTERNAL BATH
BERENDSEN, HJC
POSTMA, JPM
VANGUNSTEREN, WF
DINOLA, A
HAAK, JR
[J]. JOURNAL OF CHEMICAL PHYSICS, 1984, 81 (08) : 3684 - 3690
[2] COGEL H, 1987, J BIOL CHEM, V262, P11464
[3] ORIENTATION OF THE BACTERIORHODOPSIN CHROMOPHORE PROBED BY POLARIZED FOURIER-TRANSFORM INFRARED DIFFERENCE SPECTROSCOPY
EARNEST, TN
ROEPE, P
BRAIMAN, MS
GILLESPIE, J
ROTHSCHILD, KJ
[J]. BIOCHEMISTRY, 1986, 25 (24) : 7793 - 7798
[4] THE STRUCTURE OF A MEMBRANE-SPANNING POLYPEPTIDE STUDIED BY MOLECULAR-DYNAMICS
EDHOLM, O
JAHNIG, F
[J]. BIOPHYSICAL CHEMISTRY, 1988, 30 (03) : 279 - 292
[5] PATH OF THE POLYPEPTIDE IN BACTERIORHODOPSIN
ENGELMAN, DM
HENDERSON, R
MCLACHLAN, AD
WALLACE, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04): : 2023 - 2027
[6] FAUCHERE JL, 1983, EUR J MED CHEM, V18, P369
[7] TOPOGRAPHY OF SURFACE-EXPOSED AMINO-ACIDS IN THE MEMBRANE-PROTEIN BACTERIORHODOPSIN DETERMINED BY PROTEOLYSIS AND MICRO-SEQUENCING
FIMMEL, S
CHOLI, T
DENCHER, NA
BULDT, G
WITTMANNLIEBOLD, B
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 978 (02) : 231 - 240
[8] SOLID-STATE C-13 NMR DETECTION OF A PERTURBED 6-S-TRANS CHROMOPHORE IN BACTERIORHODOPSIN
HARBISON, GS
SMITH, SO
PARDOEN, JA
COURTIN, JML
LUGTENBURG, J
HERZFELD, J
MATHIES, RA
GRIFFIN, RG
[J]. BIOCHEMISTRY, 1985, 24 (24) : 6955 - 6962
[9] 3-DIMENSIONAL MODEL OF PURPLE MEMBRANE OBTAINED BY ELECTRON-MICROSCOPY
HENDERSON, R
UNWIN, PNT
[J]. NATURE, 1975, 257 (5521) : 28 - 32
[10] STRUCTURE OF PURPLE MEMBRANE FROM HALOBACTERIUM-HALOBIUM - RECORDING, MEASUREMENT AND EVALUATION OF ELECTRON-MICROGRAPHS AT 3.5 A RESOLUTION
HENDERSON, R
BALDWIN, JM
DOWNING, KH
LEPAULT, J
ZEMLIN, F
[J]. ULTRAMICROSCOPY, 1986, 19 (02) : 147 - 178

← 1 2 3 →