ANTAGONISM OF ESTROGEN-INDUCED AND ANTIESTROGEN-INDUCED UTERINE COMPLEMENT COMPONENT C3 EXPRESSION BY ICI-164,384

被引：13

作者：

GALMAN, MS ^{[1
]}

SUNDSTROM, SA ^{[1
]}

LYTTLE, CR ^{[1
]}

机构：

[1] UNIV PENN,DEPT OBSTET & GYNECOL,CLIN RES BLDG,RM 778,422 CURIE BLVD,PHILADELPHIA,PA 19104

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 36卷 / 04期

关键词：

D O I：

10.1016/0022-4731(90)90218-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uterus of the immature rat synthesizes and secretes complement component C3 in response to estradiol treatment. This response occurs in the uterine epithelial cells and is also stimulated by several antiestrogens including tamoxifen and LY117018. The administration of a new antiestrogen ICI 164,384 blocked the estradiol as well as the antiestrogen-stimulated increases in uterine weight, epithelial cell height, C3 synthesis and C3 mRNA. ICI 164,384 demonstrated no agonist properties in terms of epithelial cell response as determined by C3 expression. © 1990.

引用

页码：281 / 286

页数：6

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