OVARIAN STIMULATION WITH GONADOTROPIN-RELEASING-HORMONE (GNRH) ANALOG IMPROVES THE INVITRO FERTILIZATION (IVF) PREGNANCY RATE WITH BOTH TRANSVAGINAL AND LAPAROSCOPIC OOCYTE RECOVERY

被引：11

作者：

DOR, J

BENSHLOMO, I

LIPITZ, S

LEVRAN, D

ETCHIN, A

RUDAK, E

MASHIACH, S

机构：

[1] Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Ramat Gan

[2] Sackler School of Medicine, Tel Aviv University

来源：

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER | 1990年 / 7卷 / 06期

关键词：

follicular fluid pH; gonadotropin-releasing hormone (GnRH) analogue; in vitro fertilization; laparoscopy; ovulation induction; ovum pickup; transvaginal;

D O I：

10.1007/BF01130589

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The relative impact of ovarian stimulation protocal and oocyte retrieval technique on success rates of in vitro fertilization program was studied in 200 patients. Sixty-three patients received gonadotropin-releasing hormone analogue (GnRHa) with human menopausal gonadotropin (hMG), and 137 received hMG only. The GnRHa+ hMG protocol resulted in higher pregnancy rates than the hMG-only protocol (19.0 vs 9.5%, respectively; P<0.01) despite a lower cleavage rate. Oocyte retrieval was performed via laparoscopy in 100 patients and transvaginally in 100 patients. The number of oocytes recovered per cycle was 6.1±3.9 with laparoscopy and 7.0±3.1 transvaginally. Pregnancy rates were similar for both retrieval techniques (13 and 12%, respectively). A breakdown of these results showed that the advantage for the GnRHa+hMG protocol was not affected by the oocyte retrieval technique. A comparison of simultaneous blood and follicular fluid pH measured every 10 min during laparoscopy and transvaginal oocyte recovery revealed a constant decline in follicular fluid pH during laparoscopy, while no changes were observed during the vaginal procedure. We conclude that the improvement in in vitro fertilization results during the period of our study is due primarily to the introduction of GnRHa+hMG protocol rather than the method of oocyte retrieval. © 1990 Plenum Publishing Corporation.

引用

页码：351 / 354

页数：4

共 18 条

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