AMPHIPHILIC GELS FOR PEPTIDE-SYNTHESIS

被引：4

作者：

ARSHADY, R ^{[1
]}

FALLAH, F ^{[1
]}

机构：

[1] KASHAN COLL SCI,DEPT CHEM,KASHAN,IRAN

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 1992年 / 30卷 / 08期

关键词：

AMPHIPHILIC GELS; COPOLY(STYRENE-ACRYLAMIDE)S; COPOLY(STYRENE-TRICHLOROPHENYL ACRYLATE); PEPTIDE SYNTHESIS; POLYMER REACTIVITY; POLYMERIC REAGENTS; POLYMER SUPPORTS; POLYMER SWELLING;

D O I：

10.1002/pola.1992.080300823

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new class of "amphiphilic" copoly(styrene-acrylamide)s of potential interest for peptide synthesis is described. As examples of the new polymers, those carrying nitrophenol or piperazine functionality were used for model reactions in peptide synthesis, and were found to be substantially more efficient than similar reagents derived from polystyrene, polydimethylacrylamide or silica gel. Due to their amphiphilic structure, the new resins have general substrate compatibility and are permeated by all of the commonly used solvents, including toluene and ethyl acetate on the one hand, through dimethylformamide, to dimethylsulfoxide and water on the other. The improved performance of the new polymers is attributed to their alternating amphiphilic structure and favorable polymer-solvent-substrate interactions.

引用

页码：1705 / 1716

页数：12

共 31 条

[1] DEVELOPMENT OF NEW HYDROPHILIC POLYMER SUPPORTS BASED ON DIMETHYLACRYLAMIDE [J].