TRANSMEMBRANE PROTEIN OLIGOMERS OF CAPRINE ARTHRITIS-ENCEPHALITIS LENTIVIRUS ARE IMMUNODOMINANT IN GOATS WITH PROGRESSIVE ARTHRITIS

被引：42

作者：

MCGUIRE, TC ^{[1
]}

KNOWLES, DP ^{[1
]}

DAVIS, WC ^{[1
]}

BRASSFIELD, AL ^{[1
]}

STEM, TA ^{[1
]}

CHEEVERS, WP ^{[1
]}

机构：

[1] USDA ARS,ANIM DIS RES UNIT,PULLMAN,WA 99164

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 05期

关键词：

D O I：

10.1128/JVI.66.5.3247-3250.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env gene products demonstrated that gp90 was a transmembrane protein (TM) dimer. Goats with progressive arthritis had high antibody titers to oligomeric and monomeric (38-kDa) TM.

引用

页码：3247 / 3250

页数：4

共 39 条

[1] IDENTIFICATION OF CAPRINE ARTHRITIS ENCEPHALITIS RETROVIRUS PROTEINS IN IMMUNODIFFUSION PRECIPITIN LINES [J].