A NOVEL AMINO PROTECTION DEPROTECTION PROCEDURE AND ITS APPLICATION IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：23

作者：

BYCROFT, BW ^{[1
]}

CHAN, WC ^{[1
]}

CHHABRA, SR ^{[1
]}

TEESDALESPITTLE, PH ^{[1
]}

HARDY, PM ^{[1
]}

机构：

[1] UNIV EXETER,CHEM,EXETER EX4 4RJ,DEVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 09期

关键词：

D O I：

10.1039/c39930000776

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-4,4-Dimethyl-2,6-dioxocyclohexylidenemethyl (Dcm) amino acids are readily prepared and the protecting group can be removed with hydrazine at room temperature; their potential in solid phase peptide synthesis is illustrated.

引用

页码：776 / 777

页数：2

共 9 条

[1] POLYAMIDE METHOD OF SOLID-PHASE PEPTIDE AND OLIGONUCLEOTIDE SYNTHESIS
ATHERTON, E
GAIT, MJ
SHEPPARD, RC
WILLIAMS, BJ
[J]. BIOORGANIC CHEMISTRY, 1979, 8 (03) : 351 - 370
[2] Atherton E, 1989, SOLID PHASE PEPTIDE
[3] ATHERTON E, 1986, SCI TOOLS, V33, P9
[4] BARANY G, 1987, INT J PEPT PROT RES, V30, P705
[5] GROSS E, 1979, PEPTIDES ANAL SYNTHE, V1
[6] Merrifield RB, 1976, SCIENCE, V232, P341, DOI DOI 10.1126/SCIENCE.3961484
[7] MOSTI L, 1982, J HETEROCYCLIC CHEM, V19, P1355
[8] MOSTI L, 1983, J HETEROCYCLIC CHEM, V20, P645
[9] COUPLING CAPACITY OF SOLID-PHASE SEQUENCING SUPPORTS
SCHMITT, HW
WALKER, JE
[J]. FEBS LETTERS, 1977, 81 (02) : 403 - 405

← 1 →