STRUCTURE AND FUNCTION OF THE CORPUS-CALLOSUM IN SCHIZOPHRENIA - WHATS THE CONNECTION

被引：7

作者：

DAVID, AS

MINNE, C

JONES, P

HARVEY, I

RON, MA

机构：

[1] Department of Psychological Medicine, King 's College Hospital, the Institute of Psychiatry, London

[2] The Maudsley Hospital, London

[3] The Institute of Neurology, London, Queen Square

来源：

EUROPEAN PSYCHIATRY | 1995年 / 10卷 / 01期

关键词：

CORPUS CALLOSUM; MAGNETIC RESONANCE IMAGING; STROOP; HALLUCINATIONS; SCHIZOPHRENIA;

D O I：

10.1016/0767-399X(96)80072-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Tests of both structure and function of the corpus callosum have revealed abnormalities in schizophrenic patients. One such functional test employed lateralised Stroop stimuli presented tachistoscopically, to measure the transfer of interference and facilitation between the cerebral hemispheres. An attempt was made to relate indices of callosal transfer to clinical and demographic variables, including family history, as well as to indices of brain morphology. The latter included ventricle: brain ratio (VBR) measured by computed tomography (CT) scanning on 31 DSMIII schizophrenics, and the cross-sectional area of the corpus callosum from magnetic resonance imaging (MRI), obtained from 20 of these patients. VBR did nor relate to functional measures; however, anterior callosal area correlated with indices of callosal connectivity. Patients with auditory hallucinations had smaller anterior callosal areas and tended to show less connectivity. The results show links between functional and structural measures of the corpus callosum, but their precise nature remains unclear.

引用

页码：28 / 35

页数：8

共 49 条

[1]

American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, (1987)

[2]

Annett, A classification of hand preference by association analysis, Br J Psychol, 1, pp. 303-321, (1970)

[3]

Barta, Pearlson, Powers, Et al., Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia, Am J Psychiatry, 147, pp. 1457-1462, (1990)

[4]

Beaumont, Dimond, Brain disconnection and schizophrenia, Br J Psychiatry, 123, pp. 661-662, (1973)

[5]

Bech, Kastrup, Rafaelsen, Mini-compendium of rating scales for states of anxiety, depression, mania and schizophienia with corresponding DSMIII syndromes, Acta Psychiatr Scand, 73, pp. 32-37, (1986)

[6]

Benson, Zaidel, The Dual Brain, (1985)

[7]

Bigelow, Nasrallah, Rauscher, Corpus callosum thickness in chronic schizophrenia, Br J Psychiatry, 142, pp. 284-287, (1983)

[8]

Casanova, Sanders, Goldberg, Et al., Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study, J Neurol Neurosurg Psychiatry, 53, pp. 416-421, (1990)

[9]

Clarke, Lufkin, Zaidel, Corpus callosum morphometry and dichotic listening performance: individual differences in functional interhemispheric inhibition, Neuropsychologia, 31, pp. 547-557, (1993)

[10]

Clarke, Kraftsik, Van, Et al., Forms and measures of adult and developing human corpus callosum: Is there sexual dimorphism?, J Comp Neurol, 280, pp. 213-230, (1989)

← 1 2 3 4 5 →