NEURAL PATHWAYS THAT MEDIATE THE EFFECTS OF AFFERENT STIMULI ON PARAVENTRICULAR NUCLEUS MULTIUNIT ACTIVITY IN FREELY MOVING RATS

被引:17
作者
MOR, G
SAPHIER, D
FELDMAN, S
机构
[1] HADASSAH UNIV HOSP, DEPT NEUROL, NEUROPHYSIOL LAB, IL-91120 JERUSALEM, ISRAEL
[2] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, IL-91010 JERUSALEM, ISRAEL
关键词
D O I
10.1002/jnr.490170418
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The direct involvement of the hypothalamic paraventricular nucleus (PVN) in the control of adrenocortical secretion is now generally accepted. In order to contribute to our understanding of the electrical activity of cells in this region during adrenocortical activation, we have recorded multiunit electrical activity (MUA) in response to acute neural stimuli in freely moving male rats and have examined the pathways involved. Photic, acoustic, olfactory, and sciatic nerve stimulation all increased PVN MUA by between 130% and 250%. These responses were selectively blocked, according to the stimulus modality tested, by radiofrequency lesions of central neural structures. Thus PVN responses to photic stimulation were blocked by lesions of the suprachiasmatic neclei and reduced by mammilary peduncle lesions but were unaffected by lesions of the bed nuclei of the stria terminalis. Responses to acoustic stimulation were blocked by lesions of the mammilary peduncles but not by those placed in the suprachiasmatic nuclei, the septum, or the bed nuclei of the stria terminalis. Lesions of the septum blocked the response to sciatic nerve stimulation but did not affect the response to olfactory stimulation with amyl acetate fumes, which was blocked by lesions of the bed nuclei of the stria terminalis. The data confirm those obtained in endocrine studies concerning the neural pathways involved in the transmission of neural stimuli that produce adrenocortical activation.
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页码:452 / 458
页数:7
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