INHIBITORY EFFECT OF TRIETHYL LEAD ON SERUM CHOLINESTERASE IN VITRO

被引：11

作者：

GALZIGNA, L

CORSI, GC

SAIA, B

RIZZOLI, AA

机构：

来源：

CLINICA CHIMICA ACTA | 1969年 / 26卷 / 03期

关键词：

D O I：

10.1016/0009-8981(69)90064-3

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The inhibitory effect of triethyl lead, which is the main toxic metabolite of tetraethyl lead responsible for industrial intoxication, is demonstrated in vitro with a purified enzyme preparation of horse serum cholinesterase. Pyridine-2-aldoxime methiodide (PAM) and pralidoxime methylsulfate are able to restore the activity of the inhibited enzyme up to 80%. Such a reactivation allows us to consider both substances as potential antidotes for tetraethyl lead poisoning. © 1969.

引用

页码：391 / &

共 10 条

[1]

CORSI GC, 1964, MED LAVORO, V55, P411

[2]

Dixon M., 1964, ENZYMES

[3] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].