ACCUMULATION OF LOW-MOLECULAR-WEIGHT (BLEOMYCIN DETECTABLE) IRON IN BONE-MARROW CELLS OF RATS AFTER BENZENE EXPOSURE

被引：16

作者：

PANDYA, KP

RAO, GS

KHAN, S

KRISHNAMURTHY, R

机构：

[1] Industrial Toxicology Research Centre, Lucknow, 226001, Mahatma Gandhi Marg

来源：

ARCHIVES OF TOXICOLOGY | 1990年 / 64卷 / 04期

关键词：

Benzene; Bleomycin; Lipid peroxidation; Low molecular weight iron; Myelotoxicity; Superoxide radical;

D O I：

10.1007/BF01972997

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

An accumulation of low molecular weight (LMW) bleomycin detectable iron in the bone marrow was observed after administration of benzene (IP 0.5 ml/kg, daily) for 5 and 10 days in female albino rats. However, this LMW iron was not detectable in the bone marrow of rats from the control group. Studies of bone marrow fractionation showed that the maximum accumulation of this LMW iron was in the mitochondrial fraction. An increase in the activity of superoxide dismutase and lipid peroxidation was also noticed in the benzene exposed groups. © 1990 Springer-Verlag.

引用

页码：339 / 342

页数：4

共 23 条

[1] SUPEROXIDE DEPENDENT IRON RELEASE FROM FERRITIN IN INFLAMMATORY DISEASES [J].