CUTANEOUS INTERSTITIAL FLUID PROTEIN CONCENTRATIONS IN THE INFLAMMATORY SYNDROME - PHARMACOLOGICAL CONSEQUENCES

被引:11
作者
CLERC, C
PIBOUIN, M
RUELLAND, A
LEGRAS, B
CHEVRANTBRETON, J
CLOAREC, L
机构
[1] HOP HOTEL DIEU, SERV BIOCHIM A, RENNES, FRANCE
[2] HOP HOTEL DIEU, SERV DERMATOL, RENNES, FRANCE
关键词
Capillary permeability to protein; Human; Inflammatory syndrome; Interstitial fluid; Suction blister fluid;
D O I
10.1016/0009-8981(90)90090-F
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Concentrations of α1 acid glycoprotein, albumin, transferrin, haptoglobin, immunoglobulins G, A, M and apolipoprotein B were measured in serum and suction blister fluid from a group of individuals presenting a biologically proven inflammatory syndrome, and from a control group. Protein values in suction blister fluid did not change from the 2nd to the 3rd h after the beginning of blister formation. The ratio of the concentration of proteins in blister fluid and serum did not differ significantly between the groups. However, a 25% decrease in blister fluid albumin and a 100% increase in blister fluid αl acid glycoprotein, recorded in the inflammatory group, were worth noting, since they possibly influence the tissular distribution of some protein-binding drugs. Finally, an inverse relationship was established between the blister fluid/serum concentration ratio and the respective molar mass of each protein. © 1990.
引用
收藏
页码:181 / 189
页数:9
相关论文
共 16 条
[1]  
Bradford M. M., 1976, ANAL BIOCHEM, V72
[2]  
DELACROIX DL, 1982, IMMUNOLOGY, V47, P383
[3]   A quantitative theory of the precipitin reaction II. A study of an azoprotein-antibody system [J].
Heidelberger, M ;
Kendall, FE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1935, 62 (04) :467-483
[4]   SUCTION BLISTER FLUID AS A MODEL FOR INTERSTITIAL FLUID IN RATS [J].
HERFST, MJ ;
VANREES, H .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1978, 263 (03) :325-334
[6]  
Osborne J C Jr, 1977, Adv Protein Chem, V31, P253, DOI 10.1016/S0065-3233(08)60220-X
[7]  
PAXTON JW, 1983, METHOD FIND EXP CLIN, V5, P635
[8]   SOME FACTORS AFFECTING SPEED OF SUCTION BLISTER FORMATION IN NORMAL SUBJECTS [J].
PEACHEY, RDG .
BRITISH JOURNAL OF DERMATOLOGY, 1971, 84 (05) :434-&
[9]   INTERSTITIAL FLUID - EXCHANGE OF MACROMOLECULES BETWEEN PLASMA AND SKIN INTERSTITIUM [J].
ROSSING, N ;
WORM, AM .
CLINICAL PHYSIOLOGY, 1981, 1 (03) :275-284
[10]  
Rowland M, 1980, CLIN PHARMACOKINETIC