HALOTHANE ENHANCES THE BINDING OF DIAZEPAM TO SYNAPTIC-MEMBRANES FROM RAT CEREBRAL-CORTEX

The effects of halothane on diazepam binding to the rat cerebral synaptic membranes were investigated Halothane at the concentrations of 0.63, 1.3 and 4.1 mmol/1 increased the binding by 12, 23 and 33%, respectively, compared to the control in the absence of halothane. The increments were dependent on the presence of Cl-. The findings indicate that halothane and diazepam have an interaction at receptor level.