BORNA DISEASE VIRUS, A NEGATIVE-STRAND RNA VIRUS, TRANSCRIBES IN THE NUCLEUS OF INFECTED-CELLS

被引：174

作者：

BRIESE, T

DELATORRE, JC

LEWIS, A

LUDWIG, H

LIPKIN, WI

机构：

[1] UNIV CALIF IRVINE, DEPT ANAT & NEUROBIOL, IRVINE, CA 92717 USA

[2] FREE UNIV BERLIN, INST VIROL, W-1000 BERLIN 65, GERMANY

[3] UNIV CALIF IRVINE, DEPT NEUROL, IRVINE, CA 92717 USA

[4] UNIV CALIF IRVINE, DEPT MICROBIOL & MOLEC GENET, IRVINE, CA 92717 USA

[5] Scripps Res Inst, RES INST, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 23期

关键词：

CENTRAL NERVOUS SYSTEM INFECTION; BEHAVIORAL DISORDERS;

D O I：

10.1073/pnas.89.23.11486

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

引用

页码：11486 / 11489

页数：4

共 28 条

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