BIOTRANSFORMATION OF TABERSONINE IN CELL-SUSPENSION CULTURES OF CATHARANTHUS-ROSEUS

被引：18

作者：

FURUYA, T

SAKAMOTO, K

IIDA, K

ASADA, Y

YOSHIKAWA, T

SAKAI, SI

AIMI, N

机构：

[1] TONEN CORP, IRUMA, SAITAMA 354, JAPAN

[2] CHIBA UNIV, FAC PHARMACEUT SCI, CHIBA 260, JAPAN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 09期

关键词：

CATHARANTHUS-ROSEUS; AMSONIA-TABERNAEMONTANA; APOCYNANCEAE; INDOLE ALKALOIDS; VINDOLINE; LOCHNERICINE; LOCHNERININE; EPOXIDATION; CELL SUSPENSION CULTURE; BIOTRANSFORMATION;

D O I：

10.1016/0031-9422(92)83447-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the reactions involved in the biosynthesis of vindoline from tabersonine, the bioconversion products formed when the latter compound was fed to cell suspension cultures of Catharanthus roseus were isolated and characterized. Two biotransformation products of tabersonine were isolated and shown to be lochnericine, which is formed by epoxidation of tabersonine at positions 14, 15, and lochnerinine, the 11-methoxylation product of lochnericine. The bioconversion ratio of the main biotransformation product, lochnericine, reached a value of 80.6% within three days.

引用

页码：3065 / 3068

页数：4

共 34 条

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