EFFECTS OF FEEDING T-2 TOXIN AND DEOXYNIVALENOL ON DNA AND GSH CONTENTS OF BRAIN AND SPLEEN OF RATS SUPPLEMENTED WITH VITAMIN-E AND VITAMIN-C AND SELENIUM COMBINATION

被引:24
作者
ATROSHI, F
RIZZO, A
BIESE, I
SALONEN, M
LINDBERG, LA
SALONIEMI, H
机构
[1] COLL VET MED, DEPT BASIC VET SCI, HELSINKI, FINLAND
[2] COLL VET MED, DEPT PHARMACOL & TOXICOL, HELSINKI, FINLAND
[3] NATL VET & FOOD RES INST, DEPT CHEM, HELSINKI, FINLAND
关键词
D O I
10.1111/j.1439-0396.1995.tb00447.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Some mycotoxins are known to produce membrane damage through increased lipid peroxidation, which leads to impaired tissue function. An investigation of the relative importance of vitamin E, vitamin C, and selenium in rendering protection to the brain and spleen against T-2 toxin- and deoxynivalenol (DON)-induced damage was undertaken. Normal, vitamin E-, vitamin C- and selenium-supplemented, and vitamin E-, vitamin C- and selenium-deficient rats mere administered a single dose of T-2 toxin (3.6 mg/kg body weight) or DON (28 mg/kg body weight). Glutathione and DNA content were estimated in the cerebral cortex of rat brain and in spleen. Vitamin E, vitamin C, and selenium supplementation led to an increase in GSH and DNA content in brain and spleen tissues, while vitamin E, vitamin C, and selenium deficiency led to a decrease in GSH and DNA content. Administration of T-2 toxin and DON to normal rats decreases slightly, but not significantly, GSH and DNA content. The results indicate that in the brain and spleen of rats, vitamin E, vitamin C, and selenium seem to act as an antioxidant system that protects against mycotoxin-induced damage.
引用
收藏
页码:157 / 164
页数:8
相关论文
共 48 条
  • [1] HEPATIC GLUTATHIONE CONTENT AND ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY OF ACETAMINOPHEN-TREATED MICE AS A FUNCTION OF AGE
    ALTURK, WA
    STOHS, SJ
    [J]. DRUG AND CHEMICAL TOXICOLOGY, 1981, 4 (01) : 37 - 48
  • [2] VARIATION OF ERYTHROCYTE GLUTATHIONE-PEROXIDASE ACTIVITY IN FINN SHEEP
    ATROSHI, F
    SANKARI, S
    OSTERBERG, S
    SANDHOLM, M
    [J]. RESEARCH IN VETERINARY SCIENCE, 1981, 31 (03) : 267 - 271
  • [3] ATROSHI F, 1987, INT J VITAM NUTR RES, V57, P37
  • [4] THE EFFECT OF DIETARY EXPOSURE TO DON AND T-2 TOXIN ON HOST-RESISTANCE AND SERUM IMMUNOGLOBINS OF NORMAL AND MASTITIC MICE
    ATROSHI, F
    RIZZO, AF
    VEIJALAINEN, P
    LINDBERG, LA
    HONKANENBUZALSKI, T
    ANDERSSON, K
    HIRVI, T
    SALONIEMI, H
    [J]. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 1994, 71 (4-5) : 223 - 233
  • [5] ATROSHI F, 1986, RES VET SCI, V47, P1373
  • [6] ATROSHI F, 1992, LIPID SOLUBLE ANTIOX, P575
  • [7] CEREBRAL TOXICITY OF THE TRICHOTHECENE TOXIN T-2, OF THE PRODUCTS OF ITS HYDROLYSIS AND OF SOME RELATED TOXINS
    BERGMANN, F
    SOFFER, D
    YAGEN, B
    [J]. TOXICON, 1988, 26 (10) : 923 - 930
  • [8] PHOTOINACTIVATION OF CATALASE
    CHENG, L
    KELLOGG, EW
    PACKER, L
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1981, 34 (01) : 125 - 129
  • [9] MECHANISM OF INHIBITION OF EUKARYOTIC PROTEIN-SYNTHESIS BY TRICHOTHECENE FUNGAL TOXINS
    CUNDLIFFE, E
    CANNON, M
    DAVIES, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (01) : 30 - 34
  • [10] DREPPER S, 1972, SCHRIFTENREIHE VERSU, V1, P9