COMPOUNDS WITH POTENTIAL ENZYME INHIBITORY ACTIVITY . HYDROXYLAMINE ANALOGS OF 2-PROPYNYLAMINE

As a part of a study of structure-activity relationships of compounds possessing monoamine oxidase inhibitory and/or 5-hydroxytryptophan decarboxylase inhibitory activity, a series of O- or N-2-propynylhydroxylamines structurally related to pargyline has been prepared. Substituents on the hydroxylamine systems were chosen from those which have been shown to be significant in the amine series. Biological test data indicate that certain of the compounds are active enzyme inhibitors. © 1969, American Chemical Society. All rights reserved.