INHIBITION OF SOLUBLE YEAST MITOCHONDRIAL ATPASE BY ETHIDIUM-BROMIDE

被引：8

作者：

CROSBY, B

BOUTRY, M

GOFFEAU, A

机构：

[1] Laboratoire d'Enzymologie Université de Louvain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)92069-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ethidium-bromide inhibits purified yeast F1. Its inhibition yields non competitive kinetics with ATPMg and ADPMg but is competitive with 2,4 dinitrophenol. In submitochondrial particles, ethidium-bromide is competitive with para-hydroxymercuribenzoate. These data suggest a target for ethidium-bromide located at a site of F1 not involved in the hydrolysis of ATPMg. This non catalytic site also reacts with 2,4 dinitrophenol and with parahydroxymercuribenzoate. © 1979.

引用

页码：448 / 455

页数：8

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