DIFFERENCES IN CONFORMATION OF TYPE-3 POLIOVIRUS ANTIGENIC SITES ON NONINFECTIOUS EMPTY PARTICLES AND INFECTIOUS VIRUS

被引：11

作者：

FERGUSON, M

MINOR, PD

机构：

[1] National Institute for Biol., Standards and Control, South Mimms EN6 3QG, Blanche Lane

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-6-1271

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A panel of monoclonal antibodies which react with empty non-infectious type 3 poliovirus particles (C antigen) but not infectious virus (D antigen) were characterized for their reactivity with C antigen particles derived from neutralization-resistant virus strains which had single amino acid substitutions at each of the antigenic sites. Antibodies were identified which failed to bind to variant viruses with modifications at each of antigenic sites 2b, 3b and 4 indicating that the same amino acid sequences involved in the neutralization of infectious virus are also present on the surface of non-infectious particles but in different configurations.

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页码：1271 / 1274

页数：4

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