IMMUNOHISTOCHEMICAL EVIDENCE FOR THE PRESENCE OF PROTEIN-KINASE-C BETA-SUBTYPE IN RAT MOTONEURONS AND MYONEURAL JUNCTIONS

被引：17

作者：

HIETANEN, M ^{[1
]}

KOISTINAHO, J ^{[1
]}

RECHARDT, L ^{[1
]}

ROIVAINEN, R ^{[1
]}

PELTOHUIKKO, M ^{[1
]}

机构：

[1] UNIV TAMPERE,DEPT PUBL HLTH,TAMPERE,FINLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

关键词：

Immunofluorescence; Motoneuron; Motor nerve; Myoneural junction; Protein kinase C; Rat;

D O I：

10.1016/0304-3940(90)90442-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of protein kinase C β-subtype-like immunoreactivity (PKC-β-LI) was studied in the spinal cord and in different striated muscles of rat. In the spinal cord, large motoneurons in the ventral horn were PKC-β-immunoreactive (IR). Strong immunoreactivity to PKC-β was found in large nerve bundles between muscles, and in smaller nerves among muscle fibers. Myoneural junctions, which showed weaker immunoreactivity to PKC-β, were also demonstrated in all muscles studied; the external ocular muscles, the diaphragma and the triceps surae muscle. Muscle cells were not labelled. © 1990.

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页码：126 / 130

页数：5

相关论文

共 19 条

[1]

ASE K, 1988, J NEUROSCI, V8, P3850

[2] CALCITONIN GENE RELATED PEPTIDE AND MUSCLE-ACTIVITY REGULATE ACETYLCHOLINE-RECEPTOR ALPHA-SUBUNIT MESSENGER-RNA LEVELS BY DISTINCT INTRACELLULAR PATHWAYS [J].

FONTAINE, B ;

KLARSFELD, A ;

CHANGEUX, JP .

JOURNAL OF CELL BIOLOGY, 1987, 105 (03) :1337-1342

[3] IMMUNOCYTOCHEMICAL LOCALIZATION OF THE BETA-1-SUBSPECIES OF PROTEIN KINASE-C IN RAT-BRAIN [J].

HOSODA, K ;

SAITO, N ;

KOSE, A ;

ITO, A ;

TSUJINO, T ;

OGITA, K ;

KIKKAWA, U ;

ONO, Y ;

IGARASHI, K ;

NISHIZUKA, Y ;

TANAKA, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) :1393-1397

[4]

HUANG FL, 1988, J NEUROSCI, V8, P4734

[5] IDENTIFICATION OF THE STRUCTURES OF MULTIPLE SUBSPECIES OF PROTEIN-KINASE-C EXPRESSED IN RAT-BRAIN [J].

KIKKAWA, U ;

ONO, Y ;

OGITA, K ;

FUJII, T ;

ASAOKA, Y ;

SEKIGUCHI, K ;

KOSAKA, Y ;

IGARASHI, K ;

NISHIZUKA, Y .

FEBS LETTERS, 1987, 217 (02) :227-231

[6] ACETYLCHOLINE-RECEPTOR EXPRESSION IN PRIMARY CULTURES OF EMBRYONIC CHICK MYOTUBES .2. COMPARISON BETWEEN THE EFFECTS OF SPINAL-CORD CELLS AND CALCITONIN GENE-RELATED PEPTIDE [J].

KIRILOVSKY, J ;

DUCLERT, A ;

FONTAINE, B ;

DEVILLERSTHIERY, A ;

OSTERLUND, M ;

CHANGEUX, JP .

NEUROSCIENCE, 1989, 32 (02) :289-296

[7] CLONING AND EXPRESSION OF MULTIPLE PROTEIN-KINASE-C CDNAS [J].

KNOPF, JL ;

LEE, MH ;

SULTZMAN, LA ;

KRIZ, RW ;

LOOMIS, CR ;

HEWICK, RM ;

BELL, RM .

CELL, 1986, 46 (04) :491-502

[8] CALCIUM-DEPENDENT PROTEIN-KINASE - WIDESPREAD OCCURRENCE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM AND COMPARISON OF EFFECTS OF PHOSPHOLIPID, CALMODULIN, AND TRIFLUOPERAZINE [J].

KUO, JF ;

ANDERSSON, RGG ;

WISE, BC ;

MACKERLOVA, L ;

SALOMONSSON, I ;

BRACKETT, NL ;

KATOH, N ;

SHOJI, M ;

WRENN, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (12) :7039-7043

[9] STUDIES AND PERSPECTIVES OF PROTEIN-KINASE-C [J].

NISHIZUKA, Y .

SCIENCE, 1986, 233 (4761) :305-312

[10] CLONING OF RAT-BRAIN PROTEIN-KINASE-C COMPLEMENTARY-DNA [J].

ONO, Y ;

KUROKAWA, T ;

KAWAHARA, K ;

NISHIMURA, O ;

MARUMOTO, R ;

IGARASHI, K ;

SUGINO, Y ;

KIKKAWA, U ;

OGITA, K ;

NISHIZUKA, Y .

FEBS LETTERS, 1986, 203 (02) :111-115