RADIORECEPTOR ASSAY FOR BENZODIAZEPINES

被引:46
作者
HUNT, P
HUSSON, JM
RAYNAUD, JP
机构
[1] Centre de Recherches Roussel Uclaf, Romainville
关键词
D O I
10.1111/j.2042-7158.1979.tb13551.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A simple, rapid and sensitive radioreceptor assay for determining benzodiazepines in serum is based on the displacement by the drug of specific [3H]diazepam binding to a membrane fraction from rat brain. The limit of detection of the more active benzodiazepines is about 0.5 ng. Diazepam, nitrazepam, clobazam and HR 458t have been assayed in human serum after a single oral clinical dose. The results can be used for determining pharmacokinetic parameters. The technique measures not only the parent benzodiazepine but also clinically active metabolites. 1979 Royal Pharmaceutical Society of Great Britain
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页码:448 / 451
页数:4
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