MATERNALLY-DERIVED PASSIVE-IMMUNITY TO ENTEROTROPIC MOUSE HEPATITIS-VIRUS

被引：18

作者：

HOMBERGER, FR

机构：

[1] Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut

来源：

ARCHIVES OF VIROLOGY | 1992年 / 122卷 / 1-2期

关键词：

D O I：

10.1007/BF01321123

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Maternally-derived antibody to enterotropic mouse hepatitis virus (MHV) strain Y was transferred to pups by both intrauterine (IgG) and lactogenic (IgA and IgG) routes. Antibody present in the gastric whey of pups suckling immune dams dropped to undetectable levels by weaning age (21 days post partum). MHV-specific IgG was found in the serum of passively immune pups up to 10 weeks of age. Immune dams transferred equal levels of antibody to 3 consecutive litters of pups, without evidence of decline. Immunoblots showed that IgA and IgG in whey and serum were directed against nucleoprotein N and glycoprotein S. MHV-specific IgM was not detected in any sample.

引用

页码：133 / 141

页数：9

共 20 条

[1]

Barthold S. W., 1986, Viral and mycoplasmal infections of laboratory rodents. Effects on biomedical research., P571

[2]

BARTHOLD SW, 1982, LAB ANIM SCI, V32, P376

[3] MOUSE HEPATITIS-VIRUS AND HOST DETERMINANTS OF VERTICAL TRANSMISSION AND MATERNALLY-DERIVED PASSIVE-IMMUNITY IN MICE [J].