REM-SLEEP DEPRIVATION DECREASES APOMORPHINE-INDUCED STIMULATION OF LOCOMOTOR-ACTIVITY BUT NOT STEREOTYPED BEHAVIOR IN MICE

被引：42

作者：

ASAKURA, W ^{[1
]}

MATSUMOTO, K ^{[1
]}

OHTA, H ^{[1
]}

WATANABE, H ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,PHARMACOL SECT,SUGITANI,TOYAMA 93001,JAPAN

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 03期

关键词：

D O I：

10.1016/0306-3623(92)90092-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Effects of rapid eye movement (REM) sleep deprivation on central dopaminergic system were investigated by testing the behavioral responses to apomorphine and brain dopamine metabolism in mice. 2. REM sleep deprivation for 48 hr significantly suppressed apomorphine . HCl (3.0 and 6.0 mg/kg, i.p.)stimulated spontaneous locomotor activity without affecting the intensity of stereotyped behavior. 3. Neither the latency of nociceptive response in a hot-plate test nor the duration of pentobarbital-induced sleep was changed by REM sleep deprivation. 4. Dopamine turnover in the striatum and the nucleus accumbens of REM sleep-deprived mice was significantly higher than that of control animals. 5. These results suggest that REM sleep deprivation may decrease the function of postsynaptic dopamine receptor in the mesolimbic but not nigrostriatal dopaminergic system.

引用

页码：337 / 341

页数：5

共 25 条

[1] EFFECTS OF LITHIUM ON DOPAMINE BEHAVIORAL SUPERSENSITIVITY INDUCED BY RAPID EYE-MOVEMENT SLEEP-DEPRIVATION [J].

ARRIAGA, F ;

DUGOVIC, C ;

WAUQUIER, A .

NEUROPSYCHOBIOLOGY, 1988, 20 (01) :23-27

[2] DIFFERENT EFFECTS OF ACUTE AND CHRONIC STRESS ON 2 DOPAMINE-MEDIATED BEHAVIORS IN THE MOUSE [J].

CABIB, S ;

KEMPF, E ;

SCHLEEF, C ;

MELE, A ;

PUGLISIALLEGRA, S .

PHYSIOLOGY & BEHAVIOR, 1988, 43 (02) :223-227

[3] CHRONIC STRESS ENHANCES APOMORPHINE-INDUCED STEREOTYPED BEHAVIOR IN MICE - INVOLVEMENT OF ENDOGENOUS OPIOIDS [J].

CABIB, S ;

PUGLISIALLEGRA, S ;

OLIVERIO, A .

BRAIN RESEARCH, 1984, 298 (01) :138-140

[4] EFFECTS OF ELECTRIC FOOTSHOCK ON BARBITURATE SENSITIVITY, NOCICEPTION AND BODY-TEMPERATURE IN MICE [J].

CARMODY, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 89 (1-2) :119-123

[5] SLEEP-DEPRIVATION INCREASES DOPAMINE D1 RECEPTOR ANTAGONIST [H-3] SCH 23390 BINDING AND DOPAMINE-STIMULATED ADENYLATE-CYCLASE IN THE RAT LIMBIC SYSTEM [J].

DEMONTIS, MG ;

FADDA, P ;

DEVOTO, P ;

MARTELLOTTA, MC ;

FRATTA, W .

NEUROSCIENCE LETTERS, 1990, 117 (1-2) :224-227

[6] BEHAVIORAL EFFECTS OF AMPHETAMINE ON REM DEPRIVED RATS [J].

FERGUSON, J ;

DEMENT, W .

JOURNAL OF PSYCHIATRIC RESEARCH, 1969, 7 (02) :111-&

[7] CHRONIC ELECTROCONVULSIVE SHOCK AND NEUROTRANSMITTER RECEPTORS - AN UPDATE [J].

GLEITER, CH ;

NUTT, DJ .

LIFE SCIENCES, 1989, 44 (15) :985-1006

[8] INDIVIDUAL-DIFFERENCES IN THE ACCELERATING EFFECT OF METHAMPHETAMINE, D-AMPHETAMINE AND MORPHINE ON AMBULATORY ACTIVITY IN MICE [J].

HIRABAYASHI, M ;

IWAI, F ;

IIZUKA, M ;

MESAKI, T ;

ALAM, MR ;

TADOKORO, S .

FOLIA PHARMACOLOGICA JAPONICA, 1979, 75 (07) :683-693

[9]

Iverson S. D., 1977, HDB PSYCHOPHARMACOLO, V8, P333

[10]

KELLY PH, 1977, HDB PSYCHOPHARMACOLO, V8, P295

← 1 2 3 →