ANTIOXIDANT ENZYMES IN HUMAN TEARS

被引：33

作者：

CROUCH, RK

GOLETZ, P

SNYDER, A

COLES, WH

机构：

[1] Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina

[2] Department of Ophthalmology, State University of New York at Buffalo, Buffalo, New York

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1991年 / 7卷 / 03期

关键词：

D O I：

10.1089/jop.1991.7.253

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Minimally stimulated tear samples collected from human subjects were assayed for the major antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidase. No catalase or glutathione peroxidase activity was detected. However, human tear film does contain the CuZn superoxide dismutase (103 +/- 32 ng/mg soluble protein), which is inactivated by hydrogen peroxide (0.2 mM). These data indicate that the tear film has the enzyme generally required for control of inflammatory conditions but is lacking the usual physiological defense systems against the toxicity of hydrogen peroxide. Concern has been raised as to the safety of contact lens disinfectant solutions containing hydrogen peroxide. These results indicate that the tear film is lacking the enzyme systems to provide significant protection to the cornea, to the tear film itself, or to the SOD of the tear film from the oxidant action of hydrogen peroxide.

引用

页码：253 / 258

页数：6

共 22 条

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