Using Starburst Dendrimers as Linker Molecules To Radiolabel Antibodies

被引：112

作者：

Roberts, Jeanette C. ^{[1
]}

Adams, Yvonne E. ^{[1
]}

Tomalia, Donald ^{[2
]}

Mercer-Smith, Janet A. ^{[3
]}

Lavallee, David K. ^{[4
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[2] Michigan Mol Inst, Midland, MI 48640 USA

[3] Univ Calif Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[4] CUNY Hunter Coll, Dept Chem, New York, NY 10021 USA

来源：

BIOCONJUGATE CHEMISTRY | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1021/bc00005a001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Starburst dendrimers, spherical polymers constructed from methyl acrylate and ethylenediamine, were successfully used to covalently couple synthetic porphyrins to antibody molecules. The dendrimers, as linker molecules, have great potential for increasing the specific activity of radiolabeled antibodies for tumor therapy and diagnosis.

引用

页码：305 / 308

页数：4

共 7 条

[1]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[2]

CHUA MM, 1984, BIOCHIM BIOPHYS ACTA, V800, P291

[3]

MERCERSMITH JA, 1988, ANTIBODY MEDIATED DE, P317

[4]

RAMAN S, NUCL PHYS A, V131, P393

[5] PREPARATION AND CHARACTERIZATION OF COPPER-67 PORPHYRIN-ANTIBODY CONJUGATES [J].

ROBERTS, JC ;

FIGARD, SD ;

MERCERSMITH, JA ;

SVITRA, ZV ;

ANDERSON, WL ;

LAVALLEE, DK .

JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 105 (02) :153-164

[6] LABELING ANTIBODIES WITH COPPER RADIONUCLIDES USING N-4-NITROBENZYL-5-(4-CARBOXYPHENYL)-10,15,20-TRIS(4-SULFOPHENYL) PORPHINE [J].

ROBERTS, JC ;

NEWMYER, SL ;

MERCERSMITH, JA ;

SCHREYER, SA ;

LAVALLEE, DK .

APPLIED RADIATION AND ISOTOPES, 1989, 40 (09) :775-781

[7] STARBURST DENDRIMERS - MOLECULAR-LEVEL CONTROL OF SIZE, SHAPE, SURFACE-CHEMISTRY, TOPOLOGY, AND FLEXIBILITY FROM ATOMS TO MACROSCOPIC MATTER [J].

TOMALIA, DA ;

NAYLOR, AM ;

GODDARD, WA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1990, 29 (02) :138-175

← 1 →