SUCCESSFUL VACCINATION AGAINST BOOPHILUS-MICROPLUS AND BABESIA-BOVIS USING RECOMBINANT ANTIGENS

被引：13

作者：

WILLADSEN, P ^{[1
]}

KEMP, DH ^{[1
]}

COBON, GS ^{[1
]}

WRIGHT, IG ^{[1
]}

机构：

[1] BIOTECH AUSTRALIA,ROSEVILLE,NSW 2069,AUSTRALIA

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1992年 / 87卷

关键词：

VACCINATION; BOOPHILUS-MICROPLUS; BABESIA-BOVIS; RECOMBINANT ANTIGENS; FIELD TRIALS;

D O I：

10.1590/S0074-02761992000700049

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Current methods for the control of the cattle tick Boophilus microplus and the agent of bovine babesiosis, Babesia bovis are unsatisfactory. Effective immunological control of both parasites would have great advantages. However, naturally acquired immunity to the lick is generally unable to prevent serious production losses. A vaccine against the tick, based on a novel form of immunization, is being developed. A protective antigen has been isolated from the tick, characterized and produced as an effective, recombinant protein. A vaccine incorporating this antigen is currently undergoing field trials. In the Australian situation, improved tick control will probably increase endemic instability with respect to B. bovis. Fortunately, a trivalent, recombinant B. bovis vaccine has also been developed This too is now undergoing pre-registration field trials.

引用

页码：289 / 294

页数：6

共 23 条

[1] IMMUNIZATION OF CATTLE AGAINST BOOPHILUS-MICROPLUS USING EXTRACTS DERIVED FROM ADULT FEMALE TICKS - HISTOPATHOLOGY OF TICKS FEEDING ON VACCINATED CATTLE [J].