DUODENAL JUICE TOTAL PROTEIN AND PANCREATIC-ENZYME SYNTHESIS, TURNOVER, AND SECRETION IN PATIENTS AFTER ACUTE-PANCREATITIS

被引:13
作者
OGDEN, JM
OKEEFE, SJD
LOUW, JA
ADAMS, G
MARKS, IN
机构
[1] UNIV CAPE TOWN, DEPT MED, CAPE TOWN, SOUTH AFRICA
[2] MAYO CLIN & MAYO FDN, DIV GASTROENTEROL & INTERNAL MED, ROCHESTER, MN 55905 USA
关键词
D O I
10.1136/gut.34.9.1261
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
It is controversial whether acute pancreatitis has longterm effects on pancreatic function. Pancreatic enzyme synthesis, turnover, and secretion were measured in 10 patients in clinical remission who had had one or more (one to six) attacks of acute alcoholic pancreatitis. The studies were done between two and 29 months after the most recent attack. A control group included five patients with no evidence of pancreatic disease. A four hour primed/continuous intravenous infusion of [C-14]L-leucine tracer was given with secretin (2 U/kg/h) and cholecystokinin (0.5 U/kg/h) and secreted duodenal juice aspirated. Amylase and trypsin were extracted from duodenal juice by affinity chromatography, permitting measurement of the rate of isotope incorporation into total protein, amylase, and trypsin. The results showed non-parallel changes in enzyme synthesis and turnover with decreases in total enzyme protein and amylase synthesis and turnover but preservation of trypsin synthesis and turnover. The low turnover rates may be ascribed to continuing pancreatic cell malfunction after recovery from acute alcoholic pancreatitis and suggest that the decreased amylase secretion rates are partly a consequence of impaired amylase synthesis and not simply because of loss of pancreatic tissue.
引用
收藏
页码:1261 / 1266
页数:6
相关论文
共 40 条
[1]  
Ammann R W, 1986, Pancreas, V1, P195, DOI 10.1097/00006676-198605000-00001
[2]   DIAGNOSTIC VALUE OF FECAL CHYMOTRYPSIN AND TRYPSIN ASSESSMENT FOR DETECTION OF PANCREATIC DISEASE - A COMPARATIVE STUDY [J].
AMMANN, RW ;
TAGWERCHER, E ;
KASHIWAGI, H ;
ROSENMUND, H .
AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1968, 13 (02) :123-+
[3]   PANCREATIC SYNTHETIC RATES - A NEW TEST OF PANCREATIC FUNCTION [J].
BOYD, EJS ;
WOOD, H ;
CLARKE, G ;
NEILL, GD ;
HUTCHISON, F ;
WORMSLEY, KG .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1982, 17 (02) :225-231
[4]   A TEST OF PANCREATIC FUNCTION IN MAN BASED ON THE ANALYSIS OF DUODENAL CONTENTS AFTER ADMINISTRATION OF SECRETIN AND PANCREOZYMIN [J].
BURTON, P ;
EVANS, DG ;
HARPER, AA ;
HOWAT, HT ;
OLEESKY, S ;
SCOTT, JE ;
VARLEY, H .
GUT, 1960, 1 (02) :111-124
[5]  
CALVO EL, 1988, ACTA PHYSIOL PHARM L, V38, P145
[6]   A DIETARY FACTOR REGULATING THE ENZYME CONTENT OF THE PANCREAS - CHANGES INDUCED IN SIZE AND PROTEOLYTIC ACTIVITY OF THE CHICK PANCREAS BY THE INGESTION OF RAW SOY-BEAN MEAL [J].
CHERNICK, SS ;
LEPKOVSKY, S ;
CHAIKOFF, IL .
AMERICAN JOURNAL OF PHYSIOLOGY, 1948, 155 (01) :33-41
[7]  
CHOI HJ, 1967, GASTROENTEROLOGY, V53, P397
[8]   DIFFERENT ACTION OF HORMONAL-STIMULATION ON BIOSYNTHESIS OF 3 PANCREATIC-ENZYMES [J].
DAGORN, JC ;
MONGEAU, R .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 498 (01) :76-82
[9]  
DIAMOND JS, 1939, AM J DIG DIS, V6, P366
[10]   FEEDBACK-REGULATION OF STIMULATED PANCREATIC-ENZYME SECRETION DURING INTRADUODENAL PERFUSION OF TRYPSIN IN MAN [J].
DLUGOSZ, J ;
FOLSCH, UR ;
CZAJKOWSKI, A ;
GABRYELEWICZ, A .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1988, 18 (03) :267-272