ENHANCEMENT OF AMPHETAMINE-INDUCED LOCOMOTOR-ACTIVITY AND DOPAMINE RELEASE IN NUCLEUS-ACCUMBENS FOLLOWING EXCITOTOXIC LESIONS OF THE HIPPOCAMPUS

被引：102

作者：

WILKINSON, LS ^{[1
]}

MITTLEMAN, G ^{[1
]}

TORRES, E ^{[1
]}

HUMBY, T ^{[1
]}

HALL, FS ^{[1
]}

ROBBINS, TW ^{[1
]}

机构：

[1] MEMPHIS STATE UNIV,DEPT PSYCHOL,MEMPHIS,TN 38152

来源：

BEHAVIOURAL BRAIN RESEARCH | 1993年 / 55卷 / 02期

基金：

英国惠康基金;

关键词：

LOCOMOTOR ACTIVITY; HIPPOCAMPUS; NUCLEUS ACCUMBENS; D-AMPHETAMINE; MICRODIALYSIS; DOPAMINE;

D O I：

10.1016/0166-4328(93)90110-C

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study tested the hypothesis that the hippocampus modulates dopamine-dependent function of the nucleus accumbens using behavioural and neurochemical evidence. Rats with bilateral lesions of the hippocampus induced by colchicine and kainic acid exhibited equivalent levels of spontaneous locomotor activity but a potentiation of the hyperactivity produced, dose-dependently, by D-amphetamine measured in photo-cell activity cages. The same rats subsequently received unilateral implantations of a microdialysis probe aimed at the nucleus accumbens and showed elevated levels of extracellular dopamine in response to D-amphetamine but no significant difference in basal values in comparison with sham-operated controls. The results are discussed in terms of functional interactions between the hippocampus and nucleus accumbens involving the control of mesolimbic dopamine release.

引用

页码：143 / 150

页数：8

共 30 条

[1] Amaral D G, 1991, Hippocampus, V1, P415, DOI 10.1002/hipo.450010410
[2] BURNS L, 1993, BEHAV BRAIN RES, V55, P149
[3] EXCITATORY AMINO-ACID PROJECTIONS TO THE NUCLEUS-ACCUMBENS-SEPTI IN THE RAT - A RETROGRADE TRANSPORT STUDY UTILIZING D[H-3] ASPARTATE AND [H-3] GABA
CHRISTIE, MJ
SUMMERS, RJ
STEPHENSON, JA
COOK, CJ
BEART, PM
[J]. NEUROSCIENCE, 1987, 22 (02) : 425 - 439
[4] CONVERGENCE OF EXCITATORY AMYGDALOID AND HIPPOCAMPAL INPUT IN THE NUCLEUS ACCUMBENS SEPTI
DEFRANCE, JF
MARCHAND, JE
STANLEY, JC
SIKES, RW
CHRONISTER, RB
[J]. BRAIN RESEARCH, 1980, 185 (01) : 183 - 186
[5] REWARD-INDUCED STEREOTYPY - MODULATION BY THE HIPPOCAMPUS
DEVENPORT, LD
DEVENPORT, JA
HOLLOWAY, FA
[J]. SCIENCE, 1981, 212 (4500) : 1288 - 1289
[6] DWOSKIN LP, 1988, PHARM FUNCTIONAL REG
[7] ORGANIZATION OF THE PROJECTIONS FROM THE SUBICULUM TO THE VENTRAL STRIATUM IN THE RAT - A STUDY USING ANTEROGRADE TRANSPORT OF PHASEOLUS-VULGARIS LEUKOAGGLUTININ
GROENEWEGEN, HJ
VERMEULENVANDERZEE, E
KORTSCHOT, AT
WITTER, MP
[J]. NEUROSCIENCE, 1987, 23 (01) : 103 - 120
[8] SPECIFICITY IN THE PROJECTION PATTERNS OF ACCUMBAL CORE AND SHELL IN THE RAT
HEIMER, L
ZAHM, DS
CHURCHILL, L
KALIVAS, PW
WOHLTMANN, C
[J]. NEUROSCIENCE, 1991, 41 (01) : 89 - 125
[9] DOPAMINE NERVE-TERMINALS IN RAT LIMBIC CORTEX - ASPECTS OF DOPAMINE HYPOTHESIS OF SCHIZOPHRENIA
HOKFELT, T
LJUNGDAHL, A
FUXE, K
JOHANSSON, O
[J]. SCIENCE, 1974, 184 (4133) : 177 - 179
[10] DOPAMINE RELEASE IN THE NUCLEUS-CAUDATUS AND IN THE NUCLEUS-ACCUMBENS IS UNDER GLUTAMATERGIC CONTROL THROUGH NON-NMDA RECEPTORS - A STUDY IN FREELY-MOVING RATS
IMPERATO, A
HONORE, T
JENSEN, LH
[J]. BRAIN RESEARCH, 1990, 530 (02) : 223 - 228

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