SALMONELLA-TYPHI IRON UPTAKE MUTANTS ARE ATTENUATED IN MICE

被引：31

作者：

FURMAN, M

FICA, A

SAXENA, M

DIFABIO, JL

CABELLO, FC

机构：

[1] NEW YORK MED COLL,DEPT MICROBIOL & IMMUNOL,VALHALLA,NY 10595

[2] BUR BIOLOG,DIV BACTERIAL PROD,OTTAWA K1A 0L2,ON,CANADA

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 09期

关键词：

D O I：

10.1128/IAI.62.9.4091-4094.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Iron starvation interferes drastically with the multiplication and virulence of Salmonella typhi mutants defective in enterochelin synthesis or enterochelin transport. Growth of these mutants is inhibited in the presence of human sera and unsaturated transferrin and is restored by fully saturated transferrin. The mutants exhibit decreased ability to grow in HeLa cell monolayers and are attenuated in mice. These findings are consistent with the S. typhi enterochelin system playing a role in the pathogenesis of typhoid fever.

引用

页码：4091 / 4094

页数：4

共 23 条

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