REBOUND PHENOMENON OF HEPATITIS-C VIREMIA AFTER INTERFERON THERAPY IN RELAPSED PATIENTS WITH CHRONIC HEPATITIS-C

被引：2

作者：

HANADA, H

HINO, K

FUJII, K

OKAZAKI, M

OKITA, K

机构：

[1] First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, 755, Kogushi

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 03期

关键词：

CHRONIC HEPATITIS-C; INTERFERON THERAPY; HCV-RNA; AMINOTRANSFERASE;

D O I：

10.1007/BF02347510

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The correlation between serum hepatitis C virus (HCV)-RNA and aminotransferase levels following completion of interferon therapy was evaluated in eight relapsed patients with chronic hepatitis C. Both HCV-RNA and aminotransferase levels were significantly increased in the relapsed patients 1 month after completion of therapy, compared to pretreatment values, despite aminotransferase levels being normal and HCV-RNA being undetectable by reverse transcription polymerase chain reaction assay at the end of therapy. The serum levels of HCV-RNA and aminotransferase were significantly elevated 1 and 2 months post-treatment. They then decreased to pre-treatment values 3-5 months after the completion of therapy. Thus, in relapsed patients after the completion of therapy, the changes in HCV-RNA levels preceded the elevation in aminotransferase levels. These findings suggest a correlation between serum HCV-RNA levels and aminotransferase levels in relapsed patients with chronic hepatitis C after the completion of interferon therapy.

引用

页码：347 / 350

页数：4

共 18 条

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